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Comparative Study
. 1986 Oct;50(4):717-26.
doi: 10.1080/09553008614551111.

The radiosensitivity of cultured human and mouse keratinocytes

E K Parkinson, W J Hume, C S Potten
Comparative Study

The radiosensitivity of cultured human and mouse keratinocytes

E K Parkinson et al. Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Oct.

Abstract

Clonogenic survival assays after gamma-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured, keratinocytes from all sites produced survival curves which showed a reduced shoulder region and an increased D0 when compared with their freshly isolated counterparts. Freshly isolated human skin keratinocytes were more radiosensitive than mouse keratinocytes from either skin or tongue.

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