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Randomized Controlled Trial
. 2013 Dec 1:13:109.
doi: 10.1186/1471-2261-13-109.

Association between smoking status and the parameters of vascular structure and function in adults: results from the EVIDENT study

Jose I Recio-Rodriguez  1 , Manuel A Gomez-Marcos, Maria C Patino Alonso, Carlos Martin-Cantera, Elisa Ibañez-Jalon, Amor Melguizo-Bejar, Luis Garcia-Ortiz; EVIDENT Group
Collaborators, Affiliations
Randomized Controlled Trial

Association between smoking status and the parameters of vascular structure and function in adults: results from the EVIDENT study

Jose I Recio-Rodriguez et al. BMC Cardiovasc Disord. .

Abstract

Background: The present study analyses the relation between smoking status and the parameters used to assess vascular structure and function.

Methods: This cross-sectional, multi-centre study involved a random sample of 1553 participants from the EVIDENT study.

Measurements: The smoking status, peripheral augmentation index and ankle-brachial index were measured in all participants. In a small subset of the main population (265 participants), the carotid intima-media thickness and pulse wave velocity were also measured.

Results: After controlling for the effect of age, sex and other risk factors, present smokers have higher values of carotid intima-media thickness (p = 0.011). Along the same lines, current smokers have higher values of pulse wave velocity and lower mean values of ankle-brachial index but without statistical significance in both cases.

Conclusions: Among the parameters of vascular structure and function analysed, only the IMT shows association with the smoking status, after adjusting for confounders.

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Figures

Figure 1
Figure 1
Scatterplots representing the relationship between age and each vascular structure and functional parameter analysed (PWV r = 0.558; p < 0.01, IMT r = 0.687; p < 0.01, PAIx75 r = 0.222; p < 0.01 and ABI r = 0.045; p > 0.05).
Figure 2
Figure 2
Relationship between the smoking status, vascular structure and function parameters adjusted by age, sex, systolic blood pressure, heart rate, body mass index, HDL cholesterol, diabetes and the presence of antihypertensive, antidiabetic and lipid-lowering drugs. Figure represents the adjusted means and 95% CI. Statistical significance: IMT p = 0.011*, PWV p = 0.872, PAIx75 p = 0.150, ABI p = 0.464.
See this image and copyright information in PMC

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