Comparative Study
doi: 10.1038/323558a0.
The hepatitis delta (delta) virus possesses a circular RNA
- PMID: 2429192
- DOI: 10.1038/323558a0
Item in Clipboard
Comparative Study
The hepatitis delta (delta) virus possesses a circular RNA
Nature.
1986 Oct.
Abstract
Hepatitis delta (delta) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a severe form of viral hepatitis in humans. Here we present evidence based on electron microscopy and electrophoretic behaviour that HDV contains a single stranded circular RNA molecule. This is the first animal virus identified with a circular RNA genome. Circular RNAs have only been found in plant viruses. We have obtained a partial complementary DNA clone representing approximately 25% of the total genome of HDV. Analysis of this cDNA revealed similarity to two plant viruses that may explain the origin of the virus.
Similar articles
-
Molecular cloning and sequencing of a human hepatitis delta (delta) virus RNA.Nature. 1987 Sep 24-30;329(6137):343-6. doi: 10.1038/329343a0. Nature. 1987. PMID: 3627276
-
Structure, sequence and expression of the hepatitis delta (delta) viral genome.Nature. 1986 Oct 9-15;323(6088):508-14. doi: 10.1038/323508a0. Nature. 1986. PMID: 3762705
-
RNA recombination in hepatitis delta virus: implications regarding the abilities of mammalian RNA polymerases.Virus Res. 2007 Aug;127(2):208-15. doi: 10.1016/j.virusres.2007.01.003. Epub 2007 Feb 12. Virus Res. 2007. PMID: 17296240 Review.
-
RNA editing of hepatitis delta virus antigenome by dsRNA-adenosine deaminase.Nature. 1996 Apr 4;380(6573):454-6. doi: 10.1038/380454a0. Nature. 1996. PMID: 8602246
-
Molecular biologic and pathogenetic analysis of hepatitis delta virus.J Hepatol. 1995;22(1 Suppl):127-31. J Hepatol. 1995. PMID: 7602064 Review.
Cited by
-
The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells.Sci Rep. 2015 Jul 27;5:12453. doi: 10.1038/srep12453. Sci Rep. 2015. PMID: 26211738 Free PMC article.
-
CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis.Mol Cell Biochem. 2023 May;478(5):1067-1081. doi: 10.1007/s11010-022-04565-3. Epub 2022 Oct 11. Mol Cell Biochem. 2023. PMID: 36219356
-
Exploring circular RNAs as biomarkers for Parkinson's disease and their expression changes after aerobic exercise rehabilitation.Funct Integr Genomics. 2024 Jul 29;24(4):130. doi: 10.1007/s10142-024-01409-9. Funct Integr Genomics. 2024. PMID: 39069524 Review.
-
The Discovery of Hepatitis Viruses: Agents and Disease.J Clin Exp Hepatol. 2020 Jul-Aug;10(4):391-401. doi: 10.1016/j.jceh.2020.04.006. Epub 2020 Apr 20. J Clin Exp Hepatol. 2020. PMID: 32655240 Free PMC article. Review.
-
Human hepatitis delta virus RNA subfragments contain an autocleavage activity.Proc Natl Acad Sci U S A. 1989 Mar;86(6):1831-5. doi: 10.1073/pnas.86.6.1831. Proc Natl Acad Sci U S A. 1989. PMID: 2648383 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
