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Comment
. 2011 Sep 10;30(20):2504-6; discussion 2509-10.
doi: 10.1002/sim.4226.

Multivariate meta-analysis: a method to summarize non-linear associations

A Gasparrini  1 , B Armstrong
Affiliations
Comment

Multivariate meta-analysis: a method to summarize non-linear associations

A Gasparrini et al. Stat Med. .

Abstract

Multivariate meta-analysis represents a promising statistical tool in several research areas. Here, we provide a brief overview of the application of this methodology to combining complex multi-parameterized relationships, such as non-linear or delayed associations, in multi-site studies. The discussion focuses on the advantages over simpler univariate methods, estimation and computational issues and directions for further research.

Keywords: exposure-response; multivariate meta-analysis; non-linear.

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Figures

Figure 1
Figure 1
Temperature-mortality relationship (relative risk) in 4 USA cities, with reference at 20° C.
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