Role of gamma-glutamyltransferase in cardiovascular diseases
- PMID: 24294039
- PMCID: PMC3716505
Role of gamma-glutamyltransferase in cardiovascular diseases
Abstract
Cardiovascular diseases are threatening human health with rising morbidity and mortality rates. Gamma-glutamyltransferase (GGT) has been found to be involved in the pathogenesis of cardiovascular diseases, especially coronary artery disease, and the prognosis of cardiovascular disease may be predicted by increasing GGT levels. GGT levels are related to cardiovascular emergencies of chronic heart failure, and an elevated GGT level has been shown to be an independent predictive maker for cardiac death and cardiac transplantation. Investigation of the role of GGT in the mechanism of cardiac diseases will be helpful in developing preventive strategies and treatment methods.
Keywords: Coronary artery disease; Gamma-glutamyltransferase; Heart failure; Hypertension.
References
-
- Onat A, Can G, Ornek E, et al. Serum gamma-glutamyltransferase: Independent predictor of risk of diabetes, hypertension, metabolic syndrome, and coronary disease. Obesity. 2012;20:842–8. - PubMed
-
- Franzini M, Bramanti E, Ottaviano V, et al. A high performance gel filtration chromatography method for gamma-glutamyltransferase fraction analysis. Anal Biochem. 2008;374:1–6. - PubMed
-
- Dominici S, Paolicchi A, Corti A, et al. Prooxidant reactions promoted by soluble and cell-bound gamma-glutamyltransferase activity. Methods Enzymol. 2005;401:484–501. - PubMed
-
- Center SA. Diseases of the gallbladder and biliary tree. Vet Clin North Am Small Anim Pract. 2009;39:543–98. - PubMed
-
- Baral N, Pokhrel S, Lamsal M, et al. Utility of gamma-glutamyl transpeptidase and mean corpuscular volume in alcoholic liver disease. Southeast Asian J Trop Med Public Health. 2005;36:1007–10. - PubMed
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