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Comparative Study
. 1986 Aug;5(2-3):253-63.
doi: 10.1016/0168-1702(86)90022-5.

The peplomer protein sequence of the M41 strain of coronavirus IBV and its comparison with Beaudette strains

H G Niesters, J A Lenstra, W J Spaan, A J Zijderveld, N M Bleumink-Pluym, F Hong, G J van Scharrenburg, M C Horzinek, B A van der Zeijst
Comparative Study

The peplomer protein sequence of the M41 strain of coronavirus IBV and its comparison with Beaudette strains

H G Niesters et al. Virus Res. 1986 Aug.

Abstract

The amino acid sequence of the gene for the peplomer protein of the vaccine strain M41 and the Beaudette laboratory strain M42-Salk of avian infectious bronchitis virus (IBV) have been derived from cDNA sequences. As found with other coronaviruses, the peplomer protein carries the epitopes eliciting neutralizing antibodies. The gene encodes a primary translation product of 1162 amino acids with a molecular weight of 128,079. The use of a recent algorithm to predict membrane-protein interactions led to the unambiguous localization of the signal peptide and a transmembrane anchor alpha-helix at the C-terminus. At 50 positions amino acid differences were found between M41 and two Beaudette strains (M42-Salk and M42-Houghton). They are partly clustered in two regions of the protein. These two regions are candidates for neutralization epitopes of the protein.

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