Ad hoc percutaneous left atrial appendage closure

Abstract

Objectives: To investigate the feasibility of ad hoc left atrial appendage (LAA) closure in patients in atrial fibrillation.

Background: Feasibility of ad hoc LAA closure depends, among other things, on transesophageal echocardiography (TEE) being omittable.

Methods: Patients underwent ad hoc LAA closure at the same sitting as coronary angiography. TEE guidance or sedation was omitted. Left atrial access was via coexisting patent foramen ovale (PFO) or a transseptal puncture. Arriving in the left atrium, a contrast medium injection was performed, avoiding LAA intubation to exclude thrombus in the LAA. Thereafter, the 13 Fr TorqVue delivery sheath (the largest one available and compatible with all occluders) was advanced into the LAA and the diameter of the landing zone was estimated using the outer diameter of the sheath as a reference. An accordingly selected Amplatzer Cardiac Plug was deployed in the LAA.

Results: Median CHA2DS2-VASc score of the 13 included patients (8 males; age 76 years; interquartile range [IQR], 68-84 years) was 5 (IQR, 3-5) and HAS-BLED score was 3 (IQR, 2-4). Contrast medium injection to the left atrium did not reveal a thrombus in the LAA in any patient. The LAA closure procedures were uneventful and follow-up transthoracic echocardiography before discharge confirmed correct device position. Patients were discharged on acetylsalicylic acid and clopidogrel without vitamin-K antagonists.

Conclusion: Ad hoc LAA closure using local anesthesia and fluoroscopy alone appears feasible.