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Comment
. 2013 Dec;15(12):1398-400.
doi: 10.1038/ncb2891.

Life without the mitochondrial calcium uniporter

Sébastien Herzig  1 , Kinsey Maundrell, Jean-Claude Martinou
Affiliations
Comment

Life without the mitochondrial calcium uniporter

Sébastien Herzig et al. Nat Cell Biol. 2013 Dec.

Abstract

Calcium enters mitochondria through a dedicated channel referred to as the mitochondrial calcium uniporter (MCU), whose molecular identity has long remained elusive. Since the discovery of the gene encoding the MCU protein two years ago, researchers have awaited the generation of a mouse lacking the MCU. These mice are fully viable and show defects limited to performance of high-energy-demanding exercises. Strikingly, no protection against necrosis is observed following ischaemia-reperfusion in the heart.

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