Centriole biogenesis in multiciliated cells
- PMID: 24296417
- DOI: 10.1038/ncb2892
Centriole biogenesis in multiciliated cells
Abstract
Centrioles duplicate only once per cell cycle in proliferating cells, whereas in multiciliated cells, hundreds of centrioles form almost simultaneously. The molecular control mechanisms that govern centriole amplification in multiciliated cells are largely unknown. Two studies highlight Deup1 and CCDC78 as key players in this process.
Comment on
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The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.Nat Cell Biol. 2013 Dec;15(12):1434-44. doi: 10.1038/ncb2880. Epub 2013 Nov 17. Nat Cell Biol. 2013. PMID: 24240477
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