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. 2013 Dec;19(6):557-64.
doi: 10.1007/s13365-013-0216-4. Epub 2013 Dec 3.

Peripheral neuropathy in ART-experienced patients: prevalence and risk factors

Huichao Chen  1 , David B Clifford, Lijuan Deng, Kunling Wu, Anthony J Lee, Ronald J Bosch, Sharon A Riddler, Ronald J Ellis, Scott R Evans
Affiliations

Peripheral neuropathy in ART-experienced patients: prevalence and risk factors

Huichao Chen et al. J Neurovirol. 2013 Dec.

Abstract

Peripheral neuropathy (PN) is a common neurological complication of HIV infection that has debilitating effects on quality of life. While there has been a comprehensive evaluation of the prevalence of neuropathic signs/symptoms and risk factors (RFs) for PN or symptomatic PN (SPN) with initiation of combination antiretroviral therapy (cART) in ART-naïve patients, similar evaluation in ART-experienced patients is limited. This study investigated the prevalence and RFs for PN/SPN in ART-experienced patients enrolled in clinical salvage therapy studies. Between February 2000 and June 2007, 522 ART-experienced participants who experienced virologic failure with a prior regimen and started new regimens were followed longitudinally and annually screened for signs and symptoms of PN. Rates of PN/SPN at 3 years since parent study entry were 52.8 and 24.0 %, respectively. Aging, taller height, protease inhibitor use, and female sex were significant RFs for PN/SPN. The use of statin drugs was significantly associated with lower odds of SPN, and it may prevent progression from no SPN to SPN.

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Conflict of interest statement

CONFLICT OF INTEREST

Scott R. Evans has grant funding from NIH. The other authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Peripheral neuropathy over time
Figure 2
Figure 2
Estimates of association with PN, SPN, and progression from no SPN to SPN
Figure 2
Figure 2
Estimates of association with PN, SPN, and progression from no SPN to SPN
Figure 2
Figure 2
Estimates of association with PN, SPN, and progression from no SPN to SPN
See this image and copyright information in PMC

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