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Review
. 2012 May;5(1):6-11.
doi: 10.15283/ijsc.2012.5.1.6.

Delivering factors for reprogramming a somatic cell to pluripotency

Soong Ho Um  1
Affiliations
Review

Delivering factors for reprogramming a somatic cell to pluripotency

Soong Ho Um. Int J Stem Cells. 2012 May.

Abstract

An adult cell originates from stem cell. The stem cell is usually categorized into three species including an embryonic stem cell (ESc), an adult stem cell, and an induced stem cell (iPSc). iPSc features pluripotency, which is meant to be differentiated into any types of cells. Accordingly, it is much attractive to anyone who pursuit a regenerative medicine, owing to the potential almighty. They are simply produced by reprogramming a somatic cell via a transfer of transcription factors. The efficiency and productivity of iPS are considerably subject to delivering methods of exogenous genes into a variety of targeted mammalians. Conventional and well-run gene delivery techniques have been reviewed here. This details the methods and principles of delivery factors and provides an overview of the research, with an emphasis on their potential for use as clinical therapeutic platforms.

Keywords: Delivery vector; Induced stem cell.

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Figures

Fig. 1.
Fig. 1.. Generation of induced pluripotent stem cell reprogrammed from somatic cell via delivery factors.
Fig. 2.
Fig. 2.. Representative transcription factors for reprogramming.
Fig. 3.
Fig. 3.. Delivery efficiency versus toxicity for various delivery methods.
See this image and copyright information in PMC

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