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. 2013 May 16;1(2):71-3.
doi: 10.12998/wjcc.v1.i2.71.

Isolated gastric Crohn's disease

Sachin B Ingle  1 , Chitra R Hinge, Sarita Dakhure, Smita S Bhosale
Affiliations

Isolated gastric Crohn's disease

Sachin B Ingle et al. World J Clin Cases. .

Abstract

Crohn's disease (CD) is a chronic idiopathic inflammatory disease of gastrointestinal tract characterized by segmental and transmural involvement of gastrointestinal tract. Ileocolonic and colonic/anorectal is a most common and account for 40% of cases and involvement of small intestine in about 30%. The stomach is rarely the sole or predominant site of CD. To date there are only a few documented case reports of adults with isolated gastric CD and no reports in the pediatric population. Isolated stomach involvement is very unusual presentation accounting for less than 0.07% of all gastrointestinal CD. The diagnosis is difficult to establish in cases of atypical presentation as in isolated gastroduodenal disease. In the absence of any other source of disease and in the presence of nonspecific upper GI endoscopy and histological findings, serological testing can play a vital role in the diagnosis of atypical CD. Recent studies have suggested that perinuclear anti-neutrophil cytoplasmic antibody and anti-Saccharomycescervisia antibody may be used as additional diagnostic tools. The effectiveness of infliximab in isolated gastric CD is limited to only a few case reports of adult patients and the long-term outcome is unknown.

Keywords: Anti-Saccharomycescervisia antibody; Crohn’s disease; Gastrointestinal tract; Perinuclear anti-neutrophil cytoplasmic antibody.

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Figures

Figure 1
Figure 1
Section showing noncaseating granuloma (hematoxylin and eosin, × 10).
See this image and copyright information in PMC

References

    1. Ingle SB, Pujari GP, Patle YG, Nagoba BS. An unusual case of Crohn’s disease with isolated gastric involvement. J Crohns Colitis. 2011;5:69–70. - PubMed
    1. Grübel P, Choi Y, Schneider D, Knox TA, Cave DR. Severe isolated Crohn’s-like disease of the gastroduodenal tract. Dig Dis Sci. 2003;48:1360–1365. - PubMed
    1. Firth MG, Prather CM. Unusual gastric Crohn’s disease treated with infliximab - a case report. Am J Gastroenterol. 2002;97:S190.
    1. Cary ER, Tremaine WJ, Banks PM, Nagorney DM. Isolated Crohn’s disease of the stomach. Mayo Clin Proc. 1989;64:776–779. - PubMed
    1. Banerjee S, Peppercorn MA. Inflammatory bowel disease. Medical therapy of specific clinical presentations. Gastroenterol Clin North Am. 2002;31:185–202, x. - PubMed