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Review
. 2013 Sep 16;1(6):191-6.
doi: 10.12998/wjcc.v1.i6.191.

Infliximab for the treatment of pouchitis

Maddalena Zippi  1 , Claudio Cassieri, Eleonora Veronica Avallone, Roberta Pica
Affiliations
Review

Infliximab for the treatment of pouchitis

Maddalena Zippi et al. World J Clin Cases. .

Abstract

Pouchitis is not a rare complication that develops after an ileal-pouch anastomosis, performed after colectomy in patients refractory to treatment or with complicated ulcerative colitis. This condition may become chronic and unresponsive to medical therapies, including corticosteroids, antibiotics and probiotics. The advent of biological therapies (tumor necrosis factor-α inhibitors) has changed the course of these complications. In particular, in these cases, infliximab (IFX) may represent a safe and effective therapy in order to avoid the subsequent operation for a permanent ileostomy. This article reviews the therapeutic effects of one of the most widely used anti-tumor necrosis factor-α molecules, IFX, for the treatment of complicated pouchitis (refractory to conventional treatment and/or fistulizing).

Keywords: Ileal pouch-anal anastomosis; Infliximab; Pouchitis; Tumor necrosis factor-α; Ulcerative colitis.

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