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. 2013 Oct 18;25(39):5616-20.
doi: 10.1002/adma201302572.

Detection of single nanoparticles and lentiviruses using microcavity resonance broadening

Linbo Shao, Xue-Feng Jiang, Xiao-Chong Yu, Bei-Bei Li, William R Clements, Frank Vollmer, Wei Wang, Yun-Feng Xiao, Qihuang Gong

Detection of single nanoparticles and lentiviruses using microcavity resonance broadening

Linbo Shao et al. Adv Mater. .

Abstract

A new label-free sensing mechanism is demonstrated experimentally by monitoring the whispering-gallery mode broadening in microcavities. It is immune to both noise from the probe laser and environmental disturbances, and is able to remove the strict requirement for ultra-high-Q mode cavities for sensitive nanoparticle detection. This ability to sense nanoscale objects and biological analytes is particularly crucial for wide applications.

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