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Comparative Study
. 1986;66(4):340-3.

The perivascular cell populations in human skin after topical application of leukotriene B4

R K Winkelmann, R Camp, J S English, M W Greaves
  • PMID: 2430407
Comparative Study

The perivascular cell populations in human skin after topical application of leukotriene B4

R K Winkelmann et al. Acta Derm Venereol. 1986.

Abstract

Fifteen timed biopsies of human skin were performed after application of 100 nanograms of leukotriene B4 in a Finnchamber for six hours. The number of inflammatory cells were counted per high power perivascular field and compared to three control biopsies. At 24 hours a peak of neutrophiles was observed and subsequently lymphocytes predominated. Eosinophils were never prominent. This pattern of successive cell populations has been described in inflammatory and whealing skin disease.

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