Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec 5;6(1):87.
doi: 10.1186/1757-2215-6-87.

Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years' retrospective study in a developing country

Saroona Haroon  1 , Aleena Zia, Romana Idrees, Aisha Memon, Saira Fatima, Naila Kayani
Affiliations

Clinicopathological spectrum of ovarian sex cord-stromal tumors; 20 years' retrospective study in a developing country

Saroona Haroon et al. J Ovarian Res. .

Abstract

Background: Ovarian sex cord stromal tumors are rare neoplasms as compared to epithelial tumors. No large study has been done in Pakistan to find out the frequencies of various sex cord stromal tumors and their clinicopathological behavior in our region. The purpose of our study was to determine the various histological patterns and clinical features of ovarian sex cord stromal tumors along with follow-up in our set-up.

Methods: It is a retrospective observational study. The study was conducted in section of Histopathology, Aga Khan University Hospital, Karachi, Pakistan. All reported cases of sex cord stromal tumors of ovary during 1992 to 2012 were retrieved. The retrieved slides were reviewed and patient demographics, clinical and pathological features were noted on proforma. SPSS Statistics Version 19 was used for all analyses. Data is expressed as absolute values and percentage or as mean ± standard deviation (SD).

Results: A total of 480 cases of sex cord stromal tumors were retrieved. The median age was 45 years. Bilaterality was observed in 4 cases. Of the different subtypes of sex-cord stromal tumors, most common was adult granulosa cell tumor 211(43.9%). 24 Juvenile granulosa cell tumors were retrieved (5%). Other types were fibromas 98 (20.4%) fibrothecomas 47(9.8%), thecomas 26(5.4%), sertoli-leydig cell tumors 34(7%), sclerosing stromal tumors 26 (5.4%), steroid cell tumors (10) and 4 cases of sex cord tumor with annular tubules. Of various immunohistochemical stains applied, Inhibin was frequently positive in all subtypes and focal cytokeratins were also seen commonly. Follow up information was available in 305 cases and out of these only 16 (5%) developed recurrence or metastasis.

Conclusions: Sex cord stromal tumors are uncommon ovarian tumors in Pakistani population, with wide age range and diverse histological types having good prognosis. Immunohistochemical markers overlap with epithelial tumors so there is need to distinguish these two.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Gross and microscopic features of two most frequent SCSTs; Adult granulosa cell tumor and Fibroma. A) Gross appearance of Adult granulosa cell tumor. B) Microscopic picture shows coffee bean nuclei of the tumor cells present in form of sheets. (Hemotoxylin and Eosin, 40×). C) Gross picture of Fibroma. D) Microscopy shows bland nuclei with scant cytoplasm. (Hemotoxylin and Eosin, 40×).
See this image and copyright information in PMC

References

    1. Koonings PP, Campbell K, Mishell DR Jr, Grimes DA. Relative frequency of primary ovarian neoplasms: a 10-year review. Obstet Gynecol. 1989;74(6):921–926. - PubMed
    1. Shim SH, Kim DY, Lee SW, Park JY, Kim JH, Kim YM, Kim YT, Nam JH. Laparoscopic management of early-stage malignant nonepithelial ovarian tumors: surgical and survival outcomes. Int J Gynecol Cancer. 2013;23(2):249–255. doi: 10.1097/IGC.0b013e318272e754. - DOI - PubMed
    1. Aboud EA. A review of granulosa cell tumours and thecomas of the ovary. Arch Gynecol Obstet. 1997;259(4):161–165. doi: 10.1007/BF02505327. - DOI - PubMed
    1. Rosai J. In: Rosai and Ackerman’s surgical pathology. Rosai J, editor. Philadelphia7: Elsevier, Mosby; 2004. Ovary; pp. 1649–1650.
    1. Nucci MR, Oliva E. In: Sex cord-stromal tumors of the ovary. Deaver MT, Oliva E, Nucci MR, editor. Churchill Livingstone: Elsevier Churchill Livingstone; 2009. Gynecologic Pathology; pp. 457–460.

LinkOut - more resources