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. 2014 Jan;42(Database issue):D78-85.
doi: 10.1093/nar/gkt1266. Epub 2013 Dec 4.

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

Sheng-Da Hsu  1 , Yu-Ting Tseng, Sirjana Shrestha, Yu-Ling Lin, Anas Khaleel, Chih-Hung Chou, Chao-Fang Chu, Hsi-Yuan Huang, Ching-Min Lin, Shu-Yi Ho, Ting-Yan Jian, Feng-Mao Lin, Tzu-Hao Chang, Shun-Long Weng, Kuang-Wen Liao, I-En Liao, Chun-Chi Liu, Hsien-Da Huang
Affiliations

miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions

Sheng-Da Hsu et al. Nucleic Acids Res. 2014 Jan.

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules capable of negatively regulating gene expression to control many cellular mechanisms. The miRTarBase database (http://mirtarbase.mbc.nctu.edu.tw/) provides the most current and comprehensive information of experimentally validated miRNA-target interactions. The database was launched in 2010 with data sources for >100 published studies in the identification of miRNA targets, molecular networks of miRNA targets and systems biology, and the current release (2013, version 4) includes significant expansions and enhancements over the initial release (2010, version 1). This article reports the current status of and recent improvements to the database, including (i) a 14-fold increase to miRNA-target interaction entries, (ii) a miRNA-target network, (iii) expression profile of miRNA and its target gene, (iv) miRNA target-associated diseases and (v) additional utilities including an upgrade reminder and an error reporting/user feedback system.

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Figures

Figure 1.
Figure 1.
Number of miRNA-target interactions with ‘strong experimental evidence’ in TarBase version 6, miRTarBase version 1 and miRTarBase version 4.
Figure 2.
Figure 2.
miRNA-target regulatory network. Given an MTI hsa-miR-26a-5p and EZH2, miRTarBase shows a miRNA-target regulatory network consisting of all the target genes of hsa-miR-26a-5p and all the miRNAs that target EZH2.
Figure 3.
Figure 3.
Phenotype-specific correlation analysis. (A) Given an MTI hsa-miR-26a-5p and EZH2, miRTarBase shows the Pearson correlation, P-value and miRNA/mRNA expression profile for each data set. This table shows the top 4 data sets with significant P-value. (B) When the user selects a data set, miRTarBase shows the detailed profiles for hsa-miR-26a-5p and EZH2 in this data set.
See this image and copyright information in PMC

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