[Avirulent mutants of the rabies virus: change in site III of the glycoprotein]
[Article in
French]
- PMID: 2430498
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[Avirulent mutants of the rabies virus: change in site III of the glycoprotein]
[Article in
French]
Ann Rech Vet.
1986.
Abstract
Using antiglycoprotein neutralizing monoclonal antibodies, avirulent mutants of rabies virus have been selected. All these mutants have a change in the site III of the glycoprotein: Arginine 333 is replaced by either glutamine, or isoleucine, or glycine. The possibility of selecting avirulent mutants by using neutralizing monoclonal antibodies may allow to get live vaccines and to study the molecular basis of viral virulence.
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