doi: 10.1016/0013-4694(86)90189-6.
Parkinson disease: electrophysiological (CNV) analysis related to pharmacological treatment
- PMID: 2430775
- DOI: 10.1016/0013-4694(86)90189-6
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Parkinson disease: electrophysiological (CNV) analysis related to pharmacological treatment
Electroencephalogr Clin Neurophysiol.
1986 Dec.
Abstract
The contingent negative variation (CNV) was studied in a group of patients with Parkinson's disease. Testing was carried out 3 times: after a pharmacological wash-out period and at 15 and 30 days after the start of treatment with L-DOPA and bromocriptine. Peak and area CNV increased significantly after each treatment. The post-imperative negative variation (PINV) was observed in 6 out of 10 patients. The correlation found between electrophysiological functioning (CNV) measures and pharmacological treatment supports the view that dopaminergic brain activity mediates the generation of the slow negative event-related brain potentials.
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