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. 2014 Jan 3;16(1):154-7.
doi: 10.1021/ol4031233. Epub 2013 Dec 5.

Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides

Benjamin N Rocke  1 , Kevin B Bahnck, Michael Herr, Sophie Lavergne, Vincent Mascitti, Christian Perreault, Jana Polivkova, Andrei Shavnya
Affiliations

Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides

Benjamin N Rocke et al. Org Lett. .

Abstract

Organozinc reagents react with the SO2 surrogate DABSO, and the resulting zinc sulfinate salts are alkylated in situ to afford sulfones. This transformation has a broad scope and is compatible with a wide range of structural motifs of medicinal chemistry relevance including nitrile, secondary carbamates, and nitrogen-containing heterocycles.

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