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Meta-Analysis
. 2014 Feb;19(1):56-62.
doi: 10.3109/1354750X.2013.867534. Epub 2013 Dec 6.

The association of UGT1A1*6 and UGT1A1*28 with irinotecan-induced neutropenia in Asians: a meta-analysis

Yi-Jing Chen  1 , Fei Hu, Chun-Yan Li, Jue-Min Fang, Li Chu, Xi Zhang, Qing Xu
Affiliations
Meta-Analysis

The association of UGT1A1*6 and UGT1A1*28 with irinotecan-induced neutropenia in Asians: a meta-analysis

Yi-Jing Chen et al. Biomarkers. 2014 Feb.

Abstract

Background: The UGT1A1*28 polymorphism is known as a biomarker of irinotecan-induced neutropenia in Caucasians. However, in Asians, the UGT1A1*28 mutation is much less frequent.

Methods: A meta-analysis was performed to assess the association of the UGT1A1*6 and UGT1A1*28 with neutropenia in Asians.

Results: In a combination test of the two variations, patients with severe neutropenia displayed a 155% higher mutational load than those that were not neutropenic (ORG = 2.55; 95% CI: 1.82-3.58).

Conclusions: In Asians, a combination test of UGT1A1*6 and UGT1A1*28 might be a potential biomarker of irinotecan-induced neutropenia, an observation that will need additional trials for confirmation.

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