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Review
. 2013 Dec 5:6:90.
doi: 10.1186/1756-8722-6-90.

STAT inhibitors for cancer therapy

Muhammad Furqan  1 , Akintunde Akinleye, Nikhil Mukhi, Varun Mittal, Yamei Chen, Delong Liu
Affiliations
Review

STAT inhibitors for cancer therapy

Muhammad Furqan et al. J Hematol Oncol. .

Abstract

Signal Transducer and Activator of Transcription (STAT) proteins are a family of cytoplasmic transcription factors consisting of 7 members, STAT1 to STAT6, including STAT5a and STAT5b. STAT proteins are thought to be ideal targets for anti-cancer therapy since cancer cells are more dependent on the STAT activity than their normal counterparts. Inhibitors targeting STAT3 and STAT5 have been developed. These included peptidomimetics, small molecule inhibitors and oligonucleotides. This review summarized advances in preclinical and clinical development of these compounds.

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Figures

Figure 1
Figure 1
Chemical structures of peptides and peptidomimetics (a-e).
Figure 2
Figure 2
Chemical structures of small molecule inhibitors of STAT3 (a-f).
Figure 3
Figure 3
Chemical structures of small molecule inhibitors of STAT3 (a-d), STAT5 (e) and agents modulating their interactions with nuclear material (f, g).
See this image and copyright information in PMC

References

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