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Review
. 2013 Sep;26(3):269-74.
doi: 10.1016/j.beha.2013.10.007. Epub 2013 Oct 16.

New agents: great expectations not realized

Jeffrey E Lancet  1
Affiliations
Review

New agents: great expectations not realized

Jeffrey E Lancet. Best Pract Res Clin Haematol. 2013 Sep.

Abstract

A number of new agents in acute myeloid leukemia (AML) have held much promise in recent years, but most have failed to change the therapeutic landscape. Indeed, with the exception of gemtuzumab ozogamicin (which was subsequently voluntarily withdrawn from the commercial market), no new agent has been approved for acute myeloid leukemia (AML) beyond the 7 + 3 regimen, which was has been in use for over 40 years. This review touches upon the potential reasons for these failures and explores the newer therapeutic approaches being pursued in AML.

Keywords: AC220; CPX-351; FLAM; FLT3 inhibitor; acute myeloid leukemia, AML; clofarabine; flavopiridol; gemtuzumab; laromustine; lestaurtinib; lintuzumab; midostaurin; quizartinib; sapacitabine; tipifarnib.

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