Lessons from ECLIPSE: a review of COPD biomarkers

Rosa Faner¹, Ruth Tal-Singer², John H Riley³, Bartolomé Celli⁴, Jørgen Vestbo⁵, William MacNee⁶, Per Bakke⁷, Peter M A Calverley⁸, Harvey Coxson⁹, Courtney Crim¹⁰, Lisa D Edwards¹⁰, Nick Locantore¹⁰, David A Lomas¹¹, Bruce E Miller², Stephen I Rennard¹², Emiel F M Wouters¹³, Julie C Yates¹⁰, Edwin K Silverman⁴, Alvar Agusti¹⁴; ECLIPSE Study Investigators

Affiliations

¹ Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain.
² GlaxoSmithKline Research and Development, King of Prussia, Pennsylvania, USA.
³ GlaxoSmithKline Research and Development, Stevenage, UK.
⁴ Channing Division of Network Medicine and Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁵ Department of Respiratory Medicine, Odense University Hospital, and Clinical Institute, University of Southern Denmark, Odense, Denmark Respiratory and Allergy Research Group, Manchester Academic Health Sciences Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK.
⁶ University of Edinburgh, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK.
⁷ Department of Thoracic Medicine, Institute of Clinical Science, University of Bergen, Haukeland University Hospital, Bergen, Norway.
⁸ Division of Infection and Immunity Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.
⁹ Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
¹⁰ GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA.
¹¹ Division of Medicine, University College London, London, UK.
¹² Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
¹³ Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
¹⁴ Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain.

PMID: 24310110
DOI: 10.1136/thoraxjnl-2013-204778

Review

Lessons from ECLIPSE: a review of COPD biomarkers

Rosa Faner et al. Thorax. 2014 Jul.

. 2014 Jul;69(7):666-72.

doi: 10.1136/thoraxjnl-2013-204778. Epub 2013 Dec 5.

Authors

Affiliations

¹ Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain.
² GlaxoSmithKline Research and Development, King of Prussia, Pennsylvania, USA.
³ GlaxoSmithKline Research and Development, Stevenage, UK.
⁴ Channing Division of Network Medicine and Pulmonary and Critical Care Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁵ Department of Respiratory Medicine, Odense University Hospital, and Clinical Institute, University of Southern Denmark, Odense, Denmark Respiratory and Allergy Research Group, Manchester Academic Health Sciences Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK.
⁶ University of Edinburgh, MRC Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh, UK.
⁷ Department of Thoracic Medicine, Institute of Clinical Science, University of Bergen, Haukeland University Hospital, Bergen, Norway.
⁸ Division of Infection and Immunity Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK.
⁹ Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
¹⁰ GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina, USA.
¹¹ Division of Medicine, University College London, London, UK.
¹² Department of Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
¹³ Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
¹⁴ Fundació Investigació Sanitària Illes Balears (FISIB), Ciber Enfermedades Respiratorias (CIBERES), Barcelona, Catalunya, Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain.

PMID: 24310110
DOI: 10.1136/thoraxjnl-2013-204778

Abstract

The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational controlled multicentre international study aimed at defining clinically relevant subtypes of chronic obstructive pulmonary disease (COPD) and identifying novel biomarkers and genetic factors. So far, the ECLIPSE study has produced more than 50 original publications and 75 communications to international meetings, many of which have significantly influenced our understanding of COPD. However, because there is not one paper reporting the biomarker results of the ECLIPSE study that may serve as a reference for practising clinicians, researchers and healthcare providers from academia, industry and government agencies interested in COPD, we decided to write a review summarising the main biomarker findings in ECLIPSE.

Keywords: Emphysema.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

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Lessons from ECLIPSE: a review of COPD biomarkers

Affiliations

Lessons from ECLIPSE: a review of COPD biomarkers

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases