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. 2014 Jan 20;53(4):1057-61.
doi: 10.1002/anie.201307386. Epub 2013 Dec 5.

Mild bioconjugation through the oxidative coupling of ortho-aminophenols and anilines with ferricyanide

Allie C Obermeyer  1 , John B Jarman, Chawita Netirojjanakul, Kareem El Muslemany, Matthew B Francis
Affiliations

Mild bioconjugation through the oxidative coupling of ortho-aminophenols and anilines with ferricyanide

Allie C Obermeyer et al. Angew Chem Int Ed Engl. .

Abstract

Using a small-molecule-based screen, ferricyanide was identified as a mild and efficient oxidant for the coupling of anilines and o-aminophenols on protein substrates. This reaction is compatible with thiols and 1,2-diols, allowing its use in the creation of complex bioconjugates for use in biotechnology and materials applications.

Keywords: amines; bioconjugation; iron; oxidation; proteins.

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