Neonatal GATA1 mutant clones under the radar
- PMID: 24311713
- DOI: 10.1182/blood-2013-10-527598
Neonatal GATA1 mutant clones under the radar
Abstract
In this issue of Blood, Roberts et al report the comprehensive screening of a large cohort of Down syndrome neonates for the transient abnormal myelopoiesis (TAM) disorder based on blood cell morphology review and screening for GATA1 mutations, the signature genetic marker of TAM.
Comment on
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GATA1-mutant clones are frequent and often unsuspected in babies with Down syndrome: identification of a population at risk of leukemia.Blood. 2013 Dec 5;122(24):3908-17. doi: 10.1182/blood-2013-07-515148. Epub 2013 Sep 10. Blood. 2013. PMID: 24021668 Free PMC article.
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