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Meta-Analysis
. 2013 Dec 2;8(12):e81260.
doi: 10.1371/journal.pone.0081260. eCollection 2013.

Prevalence and trends of the abdominal aortic aneurysms epidemic in general population--a meta-analysis

Xi Li  1 , Ge Zhao, Jian Zhang, Zhiquan Duan, Shijie Xin
Affiliations
Meta-Analysis

Prevalence and trends of the abdominal aortic aneurysms epidemic in general population--a meta-analysis

Xi Li et al. PLoS One. .

Abstract

Objective: To conduct a meta-analysis assessing the prevalence and trends of the abdominal aortic aneurysms (AAA) epidemic in general population.

Method: Studies that reported prevalence rates of AAA from the general population were identified through MEDLINE, EMBASE, Web of Science, and reference lists for the period between 1988 and 2013. Studies were included if they reported prevalence rates of AAA in general population from the community. In stratified analyses possible sources of bias, including areas difference, age, gender and diameter of aneurysms were examined. Publication bias was assessed with Egger's test method.

Results: 56 studies were identified. The overall pooled prevalence of AAA was 4.8% (4.3%, 5.3%). Stratified analyses showed the following results, areas difference: America 2.2% (2.2%, 2.2%), Europe 2.5% (2.4%, 2.5%), Australia 6.7% (6.5%, 7.0%), Asia 0.5% (0.3%, 0.7%); gender difference: male 6.0% (5.3%, 6.7%), female 1.6% (1.2%, 1.9%); age difference: 55-64years 1.3% (1.2%, 1.5%), 65-74 years 2.8% (2.7%, 2.9%), 75-84 years1.2%(1.1%, 1.3%), ≥85years0.6% (0.4%, 0.7%); aortic diameters difference: 30-39 mm, 3.3% (2.8%, 3.9%), 40-49 mm,0.7% (0.4%,1.0%), ≥50 mm, 0.4% (0.3%, 0.5%). The prevalence of AAA has decreased in Europe from 1988 to 2013. Hypertension, smoking, coronary artery disease, dyslipidemia, respiratory disease, cerebrovascular disease, claudication and renal insufficiency were risk factors for AAA in Europe.

Conclusion: AAA is common in general population. The prevalence of AAA is higher in Australia than America and Europe. The pooled prevalence in western countries is higher than the Asia. Future research requires a larger database on the epidemiology of AAA in general population.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart demonstrating those studies that were processed for inclusion in the meta-analysis.
Figure 2
Figure 2. A forest plot of prevalence from individual studies and combined prevalence from random-effects models.
Figure 3
Figure 3. Funnel plot assessing publication bias in the prevalence of AAA from 56 published studies.
Figure 4
Figure 4. A forest plot of prevalence of AAA in Europe from 1988 to 2013.
See this image and copyright information in PMC

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