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Review
. 2013 Nov 19:3:82.
doi: 10.3389/fcimb.2013.00082. eCollection 2013.

Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress

Ilia A Droujinine  1 , Norbert Perrimon
Affiliations
Review

Defining the interorgan communication network: systemic coordination of organismal cellular processes under homeostasis and localized stress

Ilia A Droujinine et al. Front Cell Infect Microbiol. .
No abstract available

Keywords: interorgan communication network; non-cell autonomous signaling; organismal homeostasis; systemic disease; systemic stress response.

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Figures

Figure 1
Figure 1
Overview of the interorgan communication network (ICN). The ICN is the network of peptides, proteins, and metabolites that act between organs to coordinate organismal cellular processes under homeostasis and stress. Organs in the body secrete factors that act to influence the physiology of cells in distal organs. Processes that may be connected between organs include aging, protein homeostasis, nutrient uptake, metabolism, cell division, cell movement, detoxification, organelle biogenesis, and secretion of local and systemic signals. The signals may be nutrients, wastes, toxins, metabolites, nucleic acids, proteins, and peptides.
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References

    1. Ahima R. S., Prabakaran D., Mantzoros C., Qu D., Lowell B., Maratos-Flier E., et al. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252 10.1038/382250a0 - DOI - PubMed
    1. Amcheslavsky A., Jiang J., Ip Y. T. (2009). Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4, 49–61 10.1016/j.stem.2008.10.016 - DOI - PMC - PubMed
    1. Arantes-Oliveira N., Apfeld J., Dillin A., Kenyon C. (2002). Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295, 502–505 10.1126/science.1065768 - DOI - PubMed
    1. Avila F. W., Sirot L. K., LaFlamme B. A., Rubinstein C. D., Wolfner M. F. (2011). Insect seminal fluid proteins: identification and function. Annu. Rev. Entomol. 56, 21–40 10.1146/annurev-ento-120709-144823 - DOI - PMC - PubMed
    1. Barnes A. I., Wigby S., Boone J. M., Partridge L., Chapman T. (2008). Feeding, fecundity and lifespan in female Drosophila melanogaster. Proc. Biol. Sci. 275, 1675–1683 10.1098/rspb.2008.0139 - DOI - PMC - PubMed

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