Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Dec 4;80(5):1106-9.
doi: 10.1016/j.neuron.2013.11.013.

Division of labor for division: inhibitory interneurons with different spatial landscapes in the olfactory system

Naoshige Uchida  1 , Neir Eshel, Mitsuko Watabe-Uchida
Affiliations
Comment

Division of labor for division: inhibitory interneurons with different spatial landscapes in the olfactory system

Naoshige Uchida et al. Neuron. .

Abstract

Normalizing neural responses by the sum of population activity allows the nervous system to adjust its sensitivity according to task demands, facilitating intensity-invariant information processing. In this issue of Neuron, two studies, Kato et al. (2013) and Miyamichi et al. (2013), suggest that parvalbumin-positive interneurons in the olfactory bulb play a role in this process.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Different forms of gain control and the olfactory bulb
(A-C) Input gain control. (D-F) Output gain control. (G-H) Dynamic range compression. See text for mathematical and conceptual descriptions of these forms of gain control. Input-response functions are modified after Olsen et al. (2010). (J) Major neuron types in the olfactory bulb. GC, granule cell. MC, mitral cell. SA, short axon cell. TC, tufted cell. PGC, periglomerular cell. PVN, parvalbumin-expressing interneuron. ONL, olfactory nerve layer. GL, glomerular layer. EPL, external plexiform layer. MCL, mitral cell layer. GCL, granule cell layer. (K) Dendrodendritic synapse between PVN and MC dendrites.
See this image and copyright information in PMC

Comment on

References

    1. Atallah BV, Bruns W, Carandini M, Scanziani M. Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli. Neuron. 2012;73:159–170. - PMC - PubMed
    1. Carandini M, Heeger DJ. Normalization as a canonical neural computation. Nat. Rev. Neurosci. 2012;13:51–62. - PMC - PubMed
    1. Kato HK, Gillet SN, Peters AJ, Isaacson JS, Komiyama T. Parvalbumin-expressing interneurons linearly control olfactory bulb output. Neuron. 2013 - PMC - PubMed
    1. Kikuta S, Fletcher ML, Homma R, Yamasoba T, Nagayama S. Odorant response properties of individual neurons in an olfactory glomerular module. Neuron. 2013;77:1122–1135. - PMC - PubMed
    1. Miyamichi K, Shlomai-Fuchs Y, Shu M, Weissbourd BC, Luo L. Dissecting local circuits: Parvalbumin interneurons underlie broad feedback control of olfactory bulb output. Neuron. 2013 - PMC - PubMed

LinkOut - more resources