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Comment
. 2013 Dec 5;155(6):1209-10.
doi: 10.1016/j.cell.2013.11.015.

Trp'ing tuberculosis

David G Russell  1
Affiliations
Free article
Comment

Trp'ing tuberculosis

David G Russell. Cell. .
Free article

Abstract

IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-dependent drug target for tuberculosis.

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