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Review
. 2013 Dec 5;155(6):1216-9.
doi: 10.1016/j.cell.2013.11.019.

Autophagy-mediated tumor promotion

Jessie Yanxiang Guo  1 , Bing Xia, Eileen White
Affiliations
Review

Autophagy-mediated tumor promotion

Jessie Yanxiang Guo et al. Cell. .

Abstract

Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.

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Figures

Figure 1
Figure 1. Role of Autophagy in Tumor Progression and Fate
(A) Autophagy promotes mammary tumorigenesis induced by PALB2 loss. (B) Autophagy promotes the growth of KRASG12D-driven NSCLC. Lipid droplets are indicated in red, oncocytes are indicated in pink, and defective mitochondria are indicated in yellow. (C) Autophagy promotes BRAFV600E-induced lung tumor growth.
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