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Comment
. 2013 Dec 3;18(6):767-8.
doi: 10.1016/j.cmet.2013.11.011.

Adipose tissue macrophages: Amicus adipem?

Justin I Odegaard  1 , Kirthana Ganeshan, Ajay Chawla
Affiliations
Comment

Adipose tissue macrophages: Amicus adipem?

Justin I Odegaard et al. Cell Metab. .

Abstract

Chronic overnutrition drives complex adaptations within both professional metabolic and bystander tissues that, despite intense investigation, are still poorly understood. Xu et al. (2013) now describe the unexpected ability of adipose tissue macrophages to buffer lipids released from obese adipocytes in a manner independent of inflammatory macrophage activation.

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Figures

Figure 1
Figure 1. Adipose tissue macrophages buffer local lipid levels through a program of lysosomal lipid metabolism
Chronic overnutrition dramatically remodels adipose tissue architecture, driving adipocyte expansion and the infiltration of numerous immune cells, including macrophages. Triglycerides released from over-burdened adipocytes are taken up by tissue resident macrophages that function to buffer fatty acid release into circulation through a lysosome-dependent mechanism of lipid catabolism. ATM: adipose tissue macrophages.
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References

    1. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, Wang S, Fortier M, Greenberg AS, Obin MS. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005;46:2347–2355. - PubMed
    1. Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson S, Benoist C, Mathis D. PPARg is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012;486:549–553. - PMC - PubMed
    1. Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, Zechner R, Ferrante AW., Jr Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest. 2010;120:3466–3479. - PMC - PubMed
    1. Lumeng C, Bodzin J, Saltiel A. Obesity induces a phenotypic switch inadipose tissue macrophage polarization. The Journal of clinical investigation. 2007;117:175–184. - PMC - PubMed
    1. Mottillo EP, Shen XJ, Granneman JG. Role of hormone-sensitive lipase in beta-adrenergic remodeling of white adipose tissue. Am J Physiol Endocrinol Metab. 2007;293:E1188–1197. - PubMed

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