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Comment
. 2013 Dec 5;13(6):635-6.
doi: 10.1016/j.stem.2013.11.017.

Inducing cellular aging: enabling neurodegeneration-in-a-dish

Kristen J Brennand  1
Affiliations
Comment

Inducing cellular aging: enabling neurodegeneration-in-a-dish

Kristen J Brennand. Cell Stem Cell. .

Abstract

The immaturity of neurons differentiated from human induced pluripotent stem cells (hiPSCs) presents difficulties for modeling late-onset neurodegenerative disorders such as Parkinson's disease. Now, Miller et al. (2013) provide a strategy for inducing aging-related phenotypes in hiPSC-derived neurons, enabling in vitro study of late-onset neurodegenerative diseases.

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Figures

Figure 1
Figure 1. Progerin-induced cellular aging.
Ectopic expression of just one factor, progerin, is sufficient to restore cellular and molecular markers of aging in patient fibroblasts, following re-differentiation from induced pluripotent stem cells. In addition, progerin expression partially infers an “old” identity to hiPSC-derived neurons, transforming them into an ideal platform for the in vitro study of age-related neurodegenerative disorders.
See this image and copyright information in PMC

Comment on

  • Human iPSC-based modeling of late-onset disease via progerin-induced aging.
    Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu EY, Mandal PK, Vera E, Shim JW, Kriks S, Taldone T, Fusaki N, Tomishima MJ, Krainc D, Milner TA, Rossi DJ, Studer L. Miller JD, et al. Cell Stem Cell. 2013 Dec 5;13(6):691-705. doi: 10.1016/j.stem.2013.11.006. Cell Stem Cell. 2013. PMID: 24315443 Free PMC article.

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