Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

Salome Scholtens¹, Dirkje S Postma², Miriam F Moffatt³, Sviatlana Panasevich⁴, Raquel Granell⁵, A John Henderson⁵, Erik Melén⁶, Fredrik Nyberg⁷, Göran Pershagen⁴, Deborah Jarvis⁸, Adaikalavan Ramasamy⁸, Matthias Wjst⁹, Cecilie Svanes¹⁰, Emmanuelle Bouzigon¹¹, Florence Demenais¹¹, Francine Kauffmann¹², Valérie Siroux¹³, Erika von Mutius¹⁴, Markus Johannes Ege¹⁴, Charlotte Braun-Fahrländer¹⁵, Jon Genuneit¹⁶; GABRIELA study group; Bert Brunekreef¹⁷, Henriette A Smit¹⁸, Alet H Wijga¹⁹, Marjan Kerkhof¹, Ivan Curjuric¹⁵, Medea Imboden¹⁵, Gian A Thun¹⁵, Nicole Probst-Hensch¹⁵, Maxim B Freidin²⁰, Elena Iu Bragina²⁰, I A Deev²¹, V P Puzyrev²², Denise Daley²³, Julie Park²³, Allan Becker²⁴, Moira Chan-Yeung²⁵, Anita L Kozyrskyj²⁶, Peter Pare²³, Ingo Marenholz²⁷, Susanne Lau²⁸, Thomas Keil²⁹, Young-Ae Lee²⁷, Michael Kabesch³⁰, Cisca Wijmenga³¹, Lude Franke³¹, Ilja M Nolte³², Judith Vonk³², Ashish Kumar³³, Martin Farrall³⁴, William O C M Cookson³, David P Strachan³⁵, Gerard H Koppelman³⁶, H Marike Boezen³⁷

Affiliations

¹ Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
² Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
³ Division of Respiratory Sciences, Imperial College, London, United Kingdom.
⁴ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁵ ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
⁶ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Sachs' Children's Hospital, Stockholm, Sweden.
⁷ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Global Epidemiology, AstraZeneca R&D, Mölndal, Sweden.
⁸ Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.
⁹ Institute of Medical Statistics and Epidemiology (IMSE), Klinikum Rechts der Isar, Technical University, Munich, Germany; Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease (iLBD), Helmholtz Center Munich, Neuherberg, Germany.
¹⁰ Bergen Respiratory Research Group, Institute of Medicine, University of Bergen and Department of Occupational Medicine, Haukeland University Hospital Bergen, Bergen, Norway.
¹¹ Inserm U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
¹² Inserm U1018, CESP Centre for research in Epidemiology and Population Health, Respiratory and environmental epidemiology Team, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France.
¹³ Inserm U823, Centre de Recherche Albert Bonniot, La Tronche, France; Université Joseph Fourier, Grenoble, France.
¹⁴ LMU Munich, University Children's Hospital, Munich, Germany.
¹⁵ Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
¹⁶ Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
¹⁷ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁸ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
¹⁹ Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
²⁰ Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
²¹ Siberian State Medical University, Tomsk, Russia.
²² Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia.
²³ James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
²⁴ Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
²⁵ Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada.
²⁶ Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada.
²⁷ Pediatric Pneumology, Experimental and Clinical Research Center, Charité-Medical University, Berlin, Germany; Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
²⁸ Pediatric Pneumology and Immunology, Charité-Medical University, Berlin, Germany.
²⁹ Institute of Social Medicine, Epidemiology and Health Economics, Charité-Medical University, Berlin, Germany.
³⁰ Department of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
³¹ Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³² Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
³³ Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
³⁴ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
³⁵ Division of Population Health Sciences and Education, St George's, University of London, London, United Kingdom.
³⁶ Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³⁷ Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: h.m.boezen@umcg.nl.

PMID: 24315450
PMCID: PMC3969577
DOI: 10.1016/j.jaci.2013.08.049

Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

Salome Scholtens et al. J Allergy Clin Immunol. 2014 Mar.

. 2014 Mar;133(3):885-8.

doi: 10.1016/j.jaci.2013.08.049. Epub 2013 Dec 6.

Authors

Affiliations

¹ Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
² Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pulmonology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
³ Division of Respiratory Sciences, Imperial College, London, United Kingdom.
⁴ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
⁵ ALSPAC, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.
⁶ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Sachs' Children's Hospital, Stockholm, Sweden.
⁷ Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Global Epidemiology, AstraZeneca R&D, Mölndal, Sweden.
⁸ Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.
⁹ Institute of Medical Statistics and Epidemiology (IMSE), Klinikum Rechts der Isar, Technical University, Munich, Germany; Comprehensive Pneumology Center (CPC), Institute of Lung Biology and Disease (iLBD), Helmholtz Center Munich, Neuherberg, Germany.
¹⁰ Bergen Respiratory Research Group, Institute of Medicine, University of Bergen and Department of Occupational Medicine, Haukeland University Hospital Bergen, Bergen, Norway.
¹¹ Inserm U946, Genetic Variation and Human Diseases Unit, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France; Fondation Jean Dausset, Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France.
¹² Inserm U1018, CESP Centre for research in Epidemiology and Population Health, Respiratory and environmental epidemiology Team, Villejuif, France; Université Paris Sud, UMRS 1018, Villejuif, France.
¹³ Inserm U823, Centre de Recherche Albert Bonniot, La Tronche, France; Université Joseph Fourier, Grenoble, France.
¹⁴ LMU Munich, University Children's Hospital, Munich, Germany.
¹⁵ Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
¹⁶ Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
¹⁷ Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁸ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
¹⁹ Centre for Prevention and Health Services Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands.
²⁰ Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia.
²¹ Siberian State Medical University, Tomsk, Russia.
²² Research Institute of Medical Genetics of the Siberian Branch of Russian Academy of Medical Sciences, Tomsk, Russia; Siberian State Medical University, Tomsk, Russia.
²³ James Hogg iCAPTURE Center, University of British Columbia, Vancouver, British Columbia, Canada.
²⁴ Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
²⁵ Occupational and Environmental Lung Disease Unit, University of British Columbia, Vancouver, British Columbia, Canada.
²⁶ Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta and School of Public Health, University of Alberta, Edmonton, Canada.
²⁷ Pediatric Pneumology, Experimental and Clinical Research Center, Charité-Medical University, Berlin, Germany; Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
²⁸ Pediatric Pneumology and Immunology, Charité-Medical University, Berlin, Germany.
²⁹ Institute of Social Medicine, Epidemiology and Health Economics, Charité-Medical University, Berlin, Germany.
³⁰ Department of Paediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany.
³¹ Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³² Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
³³ Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
³⁴ Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
³⁵ Division of Population Health Sciences and Education, St George's, University of London, London, United Kingdom.
³⁶ Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
³⁷ Department of Epidemiology, University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: h.m.boezen@umcg.nl.

PMID: 24315450
PMCID: PMC3969577
DOI: 10.1016/j.jaci.2013.08.049

No abstract available

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References

1. Moffatt M.F., Gut I.G., Demenais F., Strachan D.P., Bouzigon E., Heath S. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363:1211–1221. - PMC - PubMed
1. UniProt Consortium Reorganizing the protein space at the Universal Protein Resource (UniProt) Nucleic Acids Res. 2012;40(Database issue):D71–D75. - PMC - PubMed
1. Dafou D., Grun B., Sinclair J., Lawrenson K., Elizabeth C., Benjamin E.C. Microcell-mediated chromosome transfer identifies EPB41L3 as a functional suppressor of epithelial ovarian cancers. Neoplasia. 2010;12:579–589. - PMC - PubMed
1. Maritz G.S., Harding R. Life-long Programming implications of exposure to tobacco smoking and nicotine before and soon after birth: evidence for altered lung development. Int J Environ Res Public Health. 2011;8:875–898. - PMC - PubMed
1. West A.B., Lockhart P.J., O'Farell C., Farrer M.J. Identification of a novel gene linked to parkin via a bi-directional promoter. J Mol Biol. 2003;326:11–19. - PubMed

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Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

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Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure

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