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. 2014 Jan;8(1):80-3.
doi: 10.1016/j.fsigen.2013.06.013. Epub 2013 Sep 7.

Population genetics of insertion-deletion polymorphisms in South Koreans using Investigator DIPplex kit

Ki Min Seong  1 , Ji Hye Park, Young Se Hyun, Pil Won Kang, Dong Ho Choi, Myun Soo Han, Ki Won Park, Ki Wha Chung
Affiliations

Population genetics of insertion-deletion polymorphisms in South Koreans using Investigator DIPplex kit

Ki Min Seong et al. Forensic Sci Int Genet. 2014 Jan.

Abstract

We assessed the applicability of 30 insertion-deletion polymorphisms (INDELs) in forensic use and the level of genetic diversity in South Korea (n=373) using the Investigator DIPplex kit (Qiagen). Allele frequencies, heterozygocities, and forensic efficacy parameters were determined. No deviation from Hardy-Weinberg equilibrium was observed for any of the INDEL markers. A high level of discrimination power was observed (combined power of discrimination: 0.99999999995). The combined match probability value was 2.84 × 10(-11) and the mean typical paternity indices were 0.878. Furthermore, we found one microvariant allele at HLD93 (rs2307570) that has not been reported. We expect that these 30 loci of INDEL markers will be useful for forensic identification and paternity testing in the South Korean population.

Keywords: Biallelic; INDEL; Insertion–deletion polymorphisms; Investigator DIPplex(®) kit; South Korean.

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