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. 2014 Mar 4;63(8):834-5.
doi: 10.1016/j.jacc.2013.10.067. Epub 2013 Dec 4.

Therapeutic drug monitoring facilitates blood pressure control in resistant hypertension

Stephanie Brinker  1 , Ambarish Pandey  2 , Colby Ayers  3 , Angela Price  1 , Prafull Raheja  1 , Debbie Arbique  1 , Sandeep R Das  3 , Ethan A Halm  2 , Norman M Kaplan  1 , Wanpen Vongpatanasin  4
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Therapeutic drug monitoring facilitates blood pressure control in resistant hypertension

Stephanie Brinker et al. J Am Coll Cardiol. .
No abstract available

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Figures

Figure 1
Figure 1. Frequency Distribution of Medication Nonadherence and Changes in BP During Follow-Up in Resistant Hypertension
(A) List of serum/plasma assays of commonly used antihypertensive drugs available for clinical testing. (B) Distribution of nonadherence ratio (the ratio of numbers of undetectable antihypertensive drugs to the total number of antihypertensive drugs tested) among subjects undergoing therapeutic drug monitoring. (C) Changes in systolic (SBP) and diastolic blood pressure (DBP) for the adherent, nonadherent, and untested groups. (*p< 0.05 vs. untested; †p< 0.05 vs. baseline; ‡p < 0.01 vs. adherent; ¶p< 0.05 vs. adherent). CPT= Current Procedural Terminology; GC = gas chromatography; HPLC = high-performance liquid chromatography; LC = liquid chromatography; MS = mass spectrometry.
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References

    1. Jung O, Gechter JL, Wunder C, et al. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens. 2013;31:766–774. - PubMed
    1. Ceral J, Habrdova V, Vorisek V, Bima M, Pelouch R, Solar M. Difficult-to-control arterial hypertension or uncooperative patients? The assessment of serum antihypertensive drug levels to differentiate non-responsiveness from non-adherence to recommended therapy. Hypertens Res. 2011;34:87–90. - PubMed
    1. Calhoun DA, Jones D, Textor S, et al. Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research. Circulation. 2008;117:e510–e526. - PubMed
    1. Esler MD, Krum H, Sobotka PA, Schlaich MP, Schmieder RE, Bohm M for the Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet. 2010;376:1903–1909. - PubMed

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