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Review
. 2014 Jan;12(1):289-95.
doi: 10.1016/j.scr.2013.11.004. Epub 2013 Nov 15.

Post-translational modifications of the histone variant H2AZ

Affiliations
Review

Post-translational modifications of the histone variant H2AZ

Ana Sevilla et al. Stem Cell Res. 2014 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Post-translational modifications of H2AZ lysines. H2AZ is methylated on lysines 4 and 7 by the methyltransferase SETD6 (Binda et al., 2013). H2AZ lysines 4, 7, 11, and 13 are acetylated, hypothetically by the acetyltransferase TIP60. Lysines 120, 121, and 125 of H2AZ are ubiquitinated by the E3 ubiquitin ligase RING1B (Sarcinella et al., 2007). H2AZub1 is deubiquitinated by the ubiquitin-specific peptidase USP10 (Draker et al., 2011).

References

    1. Albert I, Mavrich TN, Tomsho LP, Qi J, Zanton SJ, Schuster SC, Pugh BF. Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome. Nature. 2007;446:572–576. - PubMed
    1. Altaf M, Auger A, Monnet-Saksouk J, Brodeur J, Piquet S, Cramet M, Bouchard N, Lacoste N, Utley RT, Gaudreau L, Côté J. NuA4-dependent acetylation of nucleosomal histones H4 and H2A directly stimulates incorporation of H2A.Z by the SWR1 complex. J. Biol. Chem. 2010;285:15966–15977. - PMC - PubMed
    1. Amat R, Gudas LJ. RARγ is required for correct deposition and removal of Suz12 and H2A.Z in embryonic stem cells. J. Cell. Physiol. 2011;226:293–298. - PMC - PubMed
    1. Ball DJ, Slaughter CA, Hensley P, Garrard WT. Amino acid sequence of the N-terminal domain of calf thymus histone H2A.Z. FEBS Lett. 1983;154:166–170. - PubMed
    1. Bellucci L, Dalvai M, Kocanova S, Moutahir F, Bystricky K. Activation of p21 by HDAC inhibitors requires acetylation of H2A.Z. PLoS One. 2013;8:e54102. - PMC - PubMed

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