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. 1986 Dec;70(12):1451-3.

Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine

T Colombo, C Rossi, M D'Incalci
  • PMID: 2431776

Antagonism of 5-aza-2'-deoxycytidine antileukemic activity by concomitant treatment with cytarabine

T Colombo et al. Cancer Treat Rep. 1986 Dec.

Abstract

In this study we show that cytarabine given simultaneously with 5-aza-2'-deoxycytidine (Aza-dC) antagonized Aza-dC activity against L1210 mouse leukemia. This antagonism was seen after a single dose (on Day 3 or Day 5 after tumor implant) and after repeated doses. This observation suggests caution in combining cytarabine with Aza-dC in the treatment of human leukemias.

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