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. 2013:2013:384561.
doi: 10.1155/2013/384561. Epub 2013 Nov 11.

Immunochemical fecal occult blood test for detection of advanced colonic adenomas and colorectal cancer: comparison with colonoscopy results

Bianca Rosa Viana Freitas  1 , Cristiane Kibune Nagasako, Celia Regina Pavan, Sônia Letícia Silva Lorena, Fabio Guerrazzi, Cláudio Saddy Rodrigues Coy, Maria de Lourdes S Ayrizono, Maria Aparecida Mesquita
Affiliations

Immunochemical fecal occult blood test for detection of advanced colonic adenomas and colorectal cancer: comparison with colonoscopy results

Bianca Rosa Viana Freitas et al. Gastroenterol Res Pract. 2013.

Abstract

Background. Fecal immunochemical tests (FITs) have been used for colorectal cancer (CRC) screening in several countries. There is lack of information concerning diagnostic performances of this method in Brazil. Methods. Patients scheduled for elective colonoscopy provided one stool sample one week before colonoscopy. The accuracy of a qualitative FIT for detection of CRC and advanced adenomas was determined. Results. Overall 302 patients completed the study. Among them, 53.5% were high risk patients referred for screening or surveillance. Nine (3%) CRCs and 11 (3.6%) advanced adenomas were detected by colonoscopy. Sensitivity and specificity for CRC were, respectively, 88.9% and 87.6%. For advanced adenomas, sensitivity was 63.6% and specificity 87.6%. Conclusion. Our results showed good sensitivity and specificity of the FIT for detecting advanced neoplasias. This method may be a valuable tool for future screening programs in Brazil.

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Figures

Figure 1
Figure 1
Flow chart of entry into the study.
Figure 2
Figure 2
FIT positivity in relation to the colonoscopic findings.
See this image and copyright information in PMC

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