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. 2013 Jun;10(4):10.2217/pme.13.24.
doi: 10.2217/pme.13.24.

How could disclosing incidental information from whole-genome sequencing affect patient behavior?

Kurt D Christensen  1 , Robert C Green
Affiliations

How could disclosing incidental information from whole-genome sequencing affect patient behavior?

Kurt D Christensen et al. Per Med. 2013 Jun.

Abstract

In this article, we argue that disclosure of incidental findings from whole-genome sequencing has the potential to motivate individuals to change health behaviors through psychological mechanisms that differ from typical risk assessment interventions. Their ability to do so, however, is likely to be highly contingent upon the nature of the incidental findings and how they are disclosed, the context of the disclosure and the characteristics of the patient. Moreover, clinicians need to be aware that behavioral responses may occur in unanticipated ways. This article argues for commentators and policy makers to take a cautious but optimistic perspective while empirical evidence is collected through ongoing research involving whole-genome sequencing and the disclosure of incidental information.

Keywords: contextual factor; health behavior; incidental finding; whole-genome sequencing.

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References

    1. Lander ES. Initial impact of the sequencing of the human genome. Nature. 2011;470(7333):187–197. - PubMed
    1. Gilissen C, Hoischen A, Brunner H, Veltman J. Unlocking Mendelian disease using exome sequencing. Genome Biol. 2011;12(9):228. - PMC - PubMed
    1. Wolf SM, Lawrenz FP, Nelson CA, et al. Managing incidental findings in human subjects research: analysis and recommendations. J. Law Med. Ethics. 2008;36(2):219–248. - PMC - PubMed
    1. Meacham MC, Starks H, Burke W, Edwards K. Researcher perspectives on disclosure of incidental findings in genetic research. J. Empir. Res. Hum. Res. Ethics. 2010;5(3):31–41. - PMC - PubMed
    1. McBride CM, Koehly LM, Sanderson SC, Kaphingst KA. The behavioral response to personalized genetic information: will genetic risk profiles motivate individuals and families to choose more healthful behaviors? Annu. Rev. Public Health. 2010;31(1):89–103. [Excellent synthesis of the literature on whether genetic information can motivate health behavior changes.] - PubMed

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