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Comment
. 2013 Oct 15;1(4):281-2.
doi: 10.1016/j.stemcr.2013.10.002. eCollection 2013.

iPSC-Based cell therapy: an important step forward

Mahendra Rao  1
Affiliations
Comment

iPSC-Based cell therapy: an important step forward

Mahendra Rao. Stem Cell Reports. .

Abstract

Morizane et al. (2013) show that donor-matched differentiated derivatives of induced pluripotent stem cells (iPSC) do not cause an immune response after transplantation, whereas transplantation of HLA-mismatched iPSC derivatives to the same site clearly does. The importance of these results is discussed in this commentary as we assess how best to move forward with iPSC-based cell therapy.

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Figure 1
Figure 1
A Schematic Outline of the Experiment iPSC were made using viral vectors from animals that were maintained in a colony. Differentiation was performed using standard published protocols and transplants were placed within the brain.
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