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Randomized Controlled Trial
. 2013:2013:585729.
doi: 10.1155/2013/585729. Epub 2013 Nov 12.

Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study

Mitsuru Nakazawa  1 , Yukihiko Suzuki, Tadashi Ito, Tomomi Metoki, Takashi Kudo, Hiroshi Ohguro
Affiliations
Randomized Controlled Trial

Long-term effects of nilvadipine against progression of the central visual field defect in retinitis pigmentosa: an extended study

Mitsuru Nakazawa et al. Biomed Res Int. 2013.

Abstract

Purpose: To assess the long-term effects of nilvadipine on the progression of central visual field defect in retinitis pigmentosa (RP).

Methods: Patients with RP were randomly divided into a treated group receiving oral nilvadipine and a control group. Progression of RP was evaluated with MD slope and the average sensitivity of the central 2° (ΔCENT4).

Results: The mean MD slopes were -0.55/-0.39 (right/left eyes, n = 19) dB/year in the treated group and -1.37/-1.15 (right/left eyes, n = 22) dB/year in the control group (P = 0.016/0.050, resp.). In both eyes, however, no statistical difference was observed between the two groups for the ΔCENT4 values.

Conclusion: Although we confirmed that nilvadipine significantly retarded the progression of the average of MD value defects in the central 10°, it was not specific for the central 2° of the visual field in RP.

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Figures

Figure 1
Figure 1
Distribution of the MD slope for each participant during the observation periods. (a) Right eyes of the treatment group; (b) Right eyes of the control group; (c) Left eyes of the treatment group; (d) Left eyes of the control group. Black arrows indicate each patient's MD slope; blue arrows indicate the average value for each group.
See this image and copyright information in PMC

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