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. 2014;58(3):1763-7.
doi: 10.1128/AAC.02048-13. Epub 2013 Dec 9.

Susceptibility of multiresistant gram-negative bacteria to fosfomycin and performance of different susceptibility testing methods

L V Perdigão-Neto  1 , M S Oliveira, C F Rizek, C M D M Carrilho, S F Costa, A S Levin
Affiliations

Susceptibility of multiresistant gram-negative bacteria to fosfomycin and performance of different susceptibility testing methods

L V Perdigão-Neto et al. Antimicrob Agents Chemother. 2014.

Abstract

Fosfomycin may be a treatment option for multiresistant Gram-negative bacteria. This study compared susceptibility methods using 94 multiresistant clinical isolates. With agar dilution (AD), susceptibilities were 81%, 7%, 96%, and 100% (CLSI) and 0%, 0%, 96%, and 30% (EUCAST), respectively, for Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter spp. Categorical agreement between Etest and AD for Enterobacteriaceae and A. baumannii was ≥80%. Disk diffusion was adequate only for Enterobacter. CLSI criteria for urine may be adequate for systemic infections.

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Figures

FIG 1
FIG 1
Scattergram results for 200-μg fosfomycin disk zone diameters and agar dilution MICs. S, susceptible; I, intermediate susceptibility; R, resistant.
FIG 2
FIG 2
Scattergram results for 50-μg fosfomycin disk zone diameters and agar dilution MICs interpreted according to CLSI breakpoints. We included suggested disk diffusion breakpoints. S, susceptible; I, intermediate susceptibility; R, resistant.
FIG 3
FIG 3
Scattergram results for 50-μg fosfomycin disk zone diameters and agar dilution MICs interpreted according to EUCAST breakpoints. We included suggested disk diffusion breakpoints. S, susceptible; I, intermediate susceptibility; R, resistant.
See this image and copyright information in PMC

References

    1. Fritsche TR, Sader HS, Toleman MA, Walsh TR, Jones RN. 2005. Emerging metallo-beta-lactamase-mediated resistances: a summary report from the worldwide SENTRY antimicrobial surveillance program. Clin. Infect. Dis. 41:276–278 - PubMed
    1. Rice LB. 2012. Mechanisms of resistance and clinical relevance of resistance to β-lactams, glycopeptides, and fluoroquinolones. Mayo Clin. Proc. 87:198–208. 10.1016/j.mayocp.2011.12.003 - DOI - PMC - PubMed
    1. Cantón R, Lumb J. 2011. Emerging resistance in Gram-negative pathogens and implications for clinical practice. Future Microbiol. 6:19–22. 10.2217/fmb.10.150 - DOI - PubMed
    1. Cai Y, Wang R, Liang B, Bai N, Liu Y. 2011. Systematic review and meta-analysis of the effectiveness and safety of tigecycline for treatment of infectious disease. Antimicrob. Agents Chemother. 55:1162–1172. 10.1128/AAC.01402-10 - DOI - PMC - PubMed
    1. Blot S, De Waele JJ, Vogelaers D. 2012. Essentials for selecting antimicrobial therapy for intra-abdominal infections. Drugs 72:e17–e32. 10.2165/11599800-000000000-00000 - DOI - PMC - PubMed

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