Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jan;15(1):21-6.
doi: 10.5853/jos.2013.15.1.21. Epub 2013 Jan 31.

Epidemiology and registry studies of stroke in Japan

Kazunori Toyoda  1
Affiliations
Review

Epidemiology and registry studies of stroke in Japan

Kazunori Toyoda. J Stroke. 2013 Jan.

Abstract

Stroke is the most prevalent cardiovascular disease in Japan. This review introduces two epidemiologic studies and four registry studies of stroke in Japan. The Hisayama Study was begun as a population-based prospective cohort study of cerebrovascular and cardiovascular diseases in 1961 in the town of Hisayama. Most of the deceased subjects of the study underwent autopsy examinations from the beginning of the study. Changes in stroke trends in the last 50 years were clarified by comparison of data from different study cohorts registered every 13 to 14 years. The Suita Study was based on a random sampling of Japanese urban residents. Several reports from this study showed the significance of pre-hypertension, as well as hypertension, as a risk factor for stroke by itself and in combination with other underlying characteristics. In addition, the Japan Multicenter Stroke Investigators' Collaboration (J-MUSIC), the Japan Standard Stroke Registry Study, the Fukuoka Stroke Registry, and the Stroke Acute Management with Urgent Risk-factor Assessment and Improvement (SAMURAI) rt-PA Registry are explained as registry studies involving Japanese stroke patients.

Keywords: Acute stroke; Asian; Incidence; Japan; Thrombolysis.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Figure 1
Figure 1
Age-specific incidences of stroke and coronary heart disease among the 3 cohorts of the Hisayama Study, with 12-year follow-up in each cohort.
Figure 2
Figure 2
The HRs and positive fractions attributable to exposure to each blood pressure category at baseline for cardiovascular disease (including stroke): the Suita Study. The gray area displays the excessive incidence of CVD due to normal and high-normal blood pressures and hypertension stages 1 and ≥2 (From reference 10 with permission).
Figure 3
Figure 3
Percentage of subjects with asymptomatic carotid artery stenosis: the Suita Study.
See this image and copyright information in PMC

References

    1. Kim AS, Johnston SC. Global variation in the relative burden of stroke and ischemic heart disease. Circulation. 2011;124:314–323. - PubMed
    1. van Asch CJ, Luitse MJ, Rinkel GJ, van der Tweel I, Algra A, Klijn CJ. Incidence, case fatality, and functional outcome of intracerebralhaemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol. 2010;9:167–176. - PubMed
    1. Leung TW, Kwon SU, Wong KS. Management of patients with symptomatic intracranial atherosclerosis. Int J Stroke. 2006;1:20–25. - PubMed
    1. Kubo M, Kiyohara Y, Kato I, Tanizaki Y, Katafuchi R, Hirakata H, et al. Risk factors for renal glomerular and vascular changes in an autopsy-based population survey: the Hisayama study. Kidney Int. 2003;63:1508–1515. - PubMed
    1. Ueda K, Omae T, Hirota Y, Takeshita M, Katsuki S, Tanaka K, et al. Decreasing trend in incidence and mortality from stroke in Hisayama residents, Japan. Stroke. 1981;12:154–160. - PubMed

LinkOut - more resources