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. 2013 Jan;15(1):49-56.
doi: 10.5853/jos.2013.15.1.49. Epub 2013 Jan 31.

Impact of post-stroke cognitive impairment with no dementia on health-related quality of life

Jung Hyun Park  1 , Beom Joon Kim, Hee-Joon Bae, Jisung Lee, Juneyoung Lee, Moon-Ku Han, Kyung Yoon O, Seong Ho Park, Yeonwook Kang, Kyung-Ho Yu, Byung-Chul Lee
Affiliations

Impact of post-stroke cognitive impairment with no dementia on health-related quality of life

Jung Hyun Park et al. J Stroke. 2013 Jan.

Abstract

Background and purpose: Health-related quality of life (HRQoL) is a multidimensional concept that signifies a subjective evaluation of perceived health; hence, it has gained wide acceptance in geriatrics. However, its application has not been tested in patients with post-stroke cognitive impairment with no dementia (PSCIND). We investigated whether PSCIND interferes with HRQoL measured by EQ-5D, compared the findings to those of healthy people with normal cognition, and evaluated the influence of each cognitive domain on this score.

Methods: In total, 1,528 subjects were identified who had undergone neuropsychological assessment using the 60-min protocol of the Korean version of Vascular Cognitive Impairment Harmonization Standards, EQ-5D, and magnetic resonance imaging at the stroke prevention clinic. Fifty PSCIND patients were matched to 50 post-stroke dementia (PSD) patients and 50 normal age- (±3 years) and sex-matched controls. The effects of PSCIND, PSD, and control groups upon the EQ-5Dindex score were tested by generalized estimating equation modeling.

Results: Estimated means±standard errors of EQ-5Dindex scores were as follows: 0.94±0.06 (control group), 0.86±0.08 (PSCIND group), and 0.61±0.32 (PSD group); and the difference among the three groups was statistically significant (P<0.0001). Pairwise comparisons showed that EQ-5Dindex scores in the PSCIND group differed from those in the PSD and control groups (both P<0.01). No cognitive domain was specifically associated with EQ-5Dindex scores after adjusting for functional status.

Conclusions: This study shows that PSCIND may interfere with the quality of life in stroke victims.

Keywords: Dementia; Quality of life; Stroke.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart for identification of study subjects. PSCIND, post-stroke cognitive impairment with no dementia. PSD, post-stroke dementia; SVD, small vessel disease.
Figure 2
Figure 2
Distribution of subjects according to the EQ-5Dindex values and mean±SD of EQ-5Dindex in the PSD, PSCIND, and control groups.
See this image and copyright information in PMC

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