Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jan 3;20(1):58-63.
doi: 10.1002/chem.201303802. Epub 2013 Dec 10.

A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide

Xue Jiang  1 , Chao Wang, Yawen Wei, Dong Xue, Zhaotie Liu, Jianliang Xiao
Affiliations

A general method for N-methylation of amines and nitro compounds with dimethylsulfoxide

Xue Jiang et al. Chemistry. .

Erratum in

Abstract

DMSO methylates a broad range of amines in the presence of formic acid, providing a novel, green and practical method for amine methylation. The protocol also allows the one-pot transformation of aromatic nitro compounds into dimethylated amines in the presence of a simple iron catalyst.

Keywords: DMSO; amines; deuterium labelling; formic acid; methylation.

PubMed Disclaimer

Publication types

LinkOut - more resources