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Comment
. 2013 Dec;3(12):1333-5.
doi: 10.1158/2159-8290.CD-13-0790.

Teaching an old dog new tricks: drug repositioning in small cell lung cancer

Jing Wang  1 , Lauren Averett Byers
Affiliations
Comment

Teaching an old dog new tricks: drug repositioning in small cell lung cancer

Jing Wang et al. Cancer Discov. 2013 Dec.

Abstract

Jahchan and colleagues report the use of a biostatistical analysis to identify effective therapeutics for small cell lung cancer (SCLC). Their results reveal a new use for the tricyclic antidepressant imipramine in SCLC and shed light on the therapeutic potential of drug repositioning in cancer and other diseases.

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Figures

Figure 1
Figure 1. An integrated approach to drug repositioning
Publically available datasets for initial computational screens include the Connectivity Map (cMAP), Gene Expression Omnibus (GEO), Cancer Proteome Atlas, CellMiner™, Cell Line Encyclopedia (CCLE), and The Cancer Genome Atlas (TCGA).
See this image and copyright information in PMC

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References

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