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. 2013 Dec 12;369(24):2352-3.
doi: 10.1056/NEJMcibr1312709.

Macrophage accumulation in atherosclerosis

Brian W Parks, Aldons J Lusis

Macrophage accumulation in atherosclerosis

Brian W Parks et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Proliferating Macrophages in Atherosclerosis
Robbins et al. used parabiosis, the tethering of the circulatory systems of two mice (one in which the monocytes expressed the cell-surface marker CD45.1, and the other in which the monocytes expressed the cell-surface marker CD45.2), to test whether lesional macrophages mirror the chimerism of monocytes present in the combined circulatory system or whether they originate from the host mouse. Robbins et al. found that the lesional macrophages originated predominantly from the host mouse, and they concluded that the proliferation of macrophages within the atherosclerotic lesion is a driver of lesion progression.
See this image and copyright information in PMC

References

    1. Robbins CS, Hilgendorf I, Weber GF, et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013;19:1166–1172. - PMC - PubMed
    1. Chitu V, Stanley ER. Colony-stimulating factor-1 in immunity and inflammation. Curr Opin Immunol. 2006;18:39–48. - PubMed
    1. Smith JD, Trogan E, Ginsberg M, Grigaux C, Tian J, Miyata M. Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A. 1995;92:8264–8268. - PMC - PubMed
    1. Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12:204–212. - PubMed
    1. Randolph GJ. Proliferating macrophages prevail in atherosclerosis. Nat Med. 2013;19:1094–1095. - PubMed

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