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. 2014 Jan 3;16(1):266-9.
doi: 10.1021/ol403241v. Epub 2013 Dec 13.

Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp

Cong-Dat Pham  1 , Rudolf Hartmann, Philip Böhler, Björn Stork, Sebastian Wesselborg, Wenhan Lin, Daowan Lai, Peter Proksch
Affiliations

Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp

Cong-Dat Pham et al. Org Lett. .

Abstract

A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated structurally unprecedented diene-ynic side chain terminating at a brominated benzene ring. Callyspongiolide showed strong cytotoxicity against human Jurkat J16 T and Ramos B lymphocytes.

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Conflict of interest statement

Notes

The authors declare no competing financial interest.

Figures

Figure 1
Figure 1
Key COSY and HMBC correlations of 1.
Figure 2
Figure 2
Conformational analyses for the macrocyclic region of 1. (A) Rotamers determined for C4–C9 unit. (B) Rotamer determined for C12–C13 and key NOE correlations for C9–C13 backbone.
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