doi: 10.1139/y86-224.
Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation
- PMID: 2433009
- DOI: 10.1139/y86-224
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Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation
Can J Physiol Pharmacol.
1986 Oct.
Abstract
Substance P (SP), injected intrathecally, produced a dose-related increase in responsiveness (hyperalgesia) in a pressure test for nociceptive thresholds. Pretreatment with two doses of SP produced complete desensitization to this response but did not alter base-line responsiveness. The hyperalgesic response to SP and the lack of change in base line following desensitization to SP suggest a modulator rather than a transmitter role for SP in the transmission of noxious mechanical stimulation.
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